Medullary thyroid cancer diagnosis: An appraisal

被引：81

作者：

Trimboli, Pierpaolo ^{[1
]}

Giovanella, Luca ^{[2
,3
]}

Crescenzi, Anna ^{[4
,5
]}

Romanelli, Francesco ^{[6
]}

Valabrega, Stefano ^{[7
]}

Spriano, Giuseppe ^{[8
]}

Cremonini, Nadia ^{[9
]}

Guglielmi, Rinaldo ^{[10
]}

Papini, Enrico ^{[10
]}

机构：

[1] Osped Israelit, Sect Endocrinol & Diabetol, Rome, Italy

[2] Oncol Inst Southern Switzerland, Dept Nucl Med, Bellinzona, Switzerland

[3] Oncol Inst Southern Switzerland, Thyroid Ctr, Bellinzona, Switzerland

[4] Osped Israelit, Sect Pathol, Rome, Italy

[5] Osped Regina Apostolorum, Anat Pathol Unit, I-00041 Rome, Italy

[6] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy

[7] Univ Roma La Sapienza, Osped S Andrea, Dept Med & Surg Sci, Rome, Italy

[8] Ist Nazl Tumori Regina Elena, Dept Otolaryngol Head & Neck Surg, Rome, Italy

[9] Osped Maggiore Bologna, Endocrinol Unit, Bologna, Italy

[10] Osped Regina Apostolorum, Dept Endocrinol, I-00041 Rome, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2014年 / 36卷 / 08期

关键词：

thyroid; carcinoma; calcitonin; cytology; rearranged during transfection (RET); FINE-NEEDLE-ASPIRATION; RET PROTOONCOGENE MUTATIONS; SERUM CALCITONIN LEVELS; ENDOCRINE NEOPLASIA TYPE-2; WASH-OUT FLUID; ULTRASONOGRAPHIC FINDINGS; IMMUNORADIOMETRIC ASSAY; PREDICTIVE-VALUE; FOLLOW-UP; PREOPERATIVE DIAGNOSIS;

D O I：

10.1002/hed.23449

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Since its first description in 1951, a timely diagnosis of medullary thyroid carcinoma (MTC) may represent a diagnostic challenge in clinical practice. Several contributions have been addressed to the treatment and follow-up of MTC, but review articles focused on the diagnostic problems of this cancer in clinical practice are sparse. As a delayed diagnosis and an inadequate initial treatment may severely affect the prognosis of this thyroid malignancy, the appropriate use and the correct interpretation of the available diagnostic tools for MTC are of crucial importance. The purpose of the present article is to provide an easy-to-use guide reviewing the main issues of MTC diagnosis: (1) basal serum calcitonin; (2) stimulated serum calcitonin; (3) additional serum markers for MTC; (4) ultrasound and other imaging techniques; (5) fine-needle aspiration (FNA) cytology; (6) calcitonin measurement on FNA washout; (7) rearranged during transfection (RET) mutations; and (8) scope of the problem. (C) 2014 Wiley Periodicals, Inc.

引用

页码：1216 / 1223

页数：8

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