Calpains: intact and active?

被引:86
作者
Johnson, GVW
Guttmann, RP
机构
[1] Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL
关键词
D O I
10.1002/bies.950191111
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calpains are a family of calcium-dependent thiol-proteases which are proposed to be involved in many physiological processes as well as pathological conditions. Calpains are likely to be involved in processing of numerous enzymes and cytoskeletal components, thereby linking their activity to a variety of intracellular events. Although widely studied, the precise mechanism(s) involved in calpain activation and activity in vivo remain poorly understood. Initial studies suggested that calpain exists primarily as an inactive proenzyme that required autolytic cleavage for activation. It was also hypothesized that calpain associated with membrane phospholipids, serving to increase calcium sensitivity, facilitating autolytic conversion and thus activating the enzyme. These hypotheses, however, have not been universally accepted and there is increasing evidence that intact, non-autolyzed calpain is the physiologically active calpain form.
引用
收藏
页码:1011 / 1018
页数:8
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共 70 条
[61]  
SUZUKI K, 1995, BIOL CHEM H-S, V376, P523
[62]   PIG-HEART CALPASTATIN - IDENTIFICATION OF REPETITIVE DOMAIN-STRUCTURES AND ANOMALOUS BEHAVIOR IN POLYACRYLAMIDE-GEL ELECTROPHORESIS [J].
TAKANO, E ;
MAKI, M ;
MORI, H ;
HATANAKA, M ;
MARTI, T ;
TITANI, K ;
KANNAGI, R ;
OOI, T ;
MURACHI, T .
BIOCHEMISTRY, 1988, 27 (06) :1964-1972
[63]   PREFERENCE OF CALCIUM-DEPENDENT INTERACTIONS BETWEEN CALMODULIN-LIKE DOMAINS OF CALPAIN AND CALPASTATIN SUBDOMAINS [J].
TAKANO, E ;
MA, H ;
YANG, HQ ;
MAKI, M ;
HATANAKA, M .
FEBS LETTERS, 1995, 362 (01) :93-97
[64]   The Calpain cascade - mu-Calpain activates m-Calpain [J].
Tompa, P ;
Baki, A ;
Schad, E ;
Friedrich, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) :33161-33164
[65]   CHARACTERIZATION OF A FUNCTIONAL DOMAIN OF HUMAN CALPASTATIN [J].
UEMORI, T ;
SHIMOJO, T ;
ASADA, K ;
ASANO, T ;
KIMIZUKA, F ;
KATO, I ;
MAKI, M ;
HATANAKA, M ;
MURACHI, T ;
HANZAWA, H ;
ARATA, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 166 (03) :1485-1493
[66]  
YANG HQ, 1994, J BIOL CHEM, V269, P18977
[67]   A CATALYTIC SUBUNIT OF CALPAIN POSSESSES FULL PROTEOLYTIC ACTIVITY [J].
YOSHIZAWA, T ;
SORIMACHI, H ;
TOMIOKA, S ;
ISHIURA, S ;
SUZUKI, K .
FEBS LETTERS, 1995, 358 (01) :101-103
[68]   The major calpain isozymes are long-lived proteins - Design of an antisense strategy for calpain depletion in cultured cells [J].
Zhang, WL ;
Lane, RD ;
Mellgren, RL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18825-18830
[69]   Calpain subunits remain associated during catalysis [J].
Zhang, WL ;
Mellgren, RL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 227 (03) :890-896
[70]   2-STAGE AUTOLYSIS OF THE CATALYTIC SUBUNIT INITIATES ACTIVATION OF CALPAIN-I [J].
ZIMMERMAN, UJP ;
SCHLAEPFER, WW .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1078 (02) :192-198