Photosensitive liposomes as 'cages' for laser-triggered solute delivery: the effect of bilayer cholesterol on kinetics of solute release

被引：33

作者：

Bisby, RH ^{[1
]}

Mead, C ^{[1
]}

Morgan, CG ^{[1
]}

机构：

[1] Univ Salford, Biosci Div, Sch Environm & Life Sci, Salford M5 4WT, Lancs, England

来源：

FEBS LETTERS | 1999年 / 463卷 / 1-2期

基金：

英国生物技术与生命科学研究理事会;

关键词：

liposome; caged reagent; azobenzene; photosensitization; drug delivery; photodynamic therapy;

D O I：

10.1016/S0014-5793(99)01612-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes containing acyl chains incorporating azobenzene chromophores have been investigated as potential 'caging' agents for fast solute release, On photolysis, trapped marl;er dye can be released from gel-phase liposomes within milliseconds. Solute release is markedly sensitive to the presence of cholesterol in the bilayer, Phospholipids bearing one saturated acyl chain and an azobenzene-substituted chain are ineffective as sensitisers unless cholesterol is present, while doubly substituted phospholipids sensitise release in its absence. Cholesterol markedly affects the temperature profile of solute release depending on the host phospholipid chain length. Solute release is not seen for lipid hosts,vith unsaturated acyl chains. (C) 1999 Federation of European Biochemical Societies.

引用

页码：165 / 168

页数：4

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