The anaphase promoting complex/cyclosome: a machine designed to destroy

被引：1017

作者：

Peters, Jan-Michael ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 09期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1038/nrm1988

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

引用

收藏

页码：644 / 656

页数：13

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共 168 条

[81] Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20 [J].

Morrow, CJ ;

Tighe, A ;

Johnson, VL ;

Scott, MIF ;

Ditchfield, C ;

Taylor, SS .

JOURNAL OF CELL SCIENCE, 2005, 118 (16) :3639-3652

[82] Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome [J].

Moshe, Y ;

Boulaire, J ;

Pagano, M ;

Hershko, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (21) :7937-7942

[83] THE ROLE OF CYCLIN SYNTHESIS AND DEGRADATION IN THE CONTROL OF MATURATION PROMOTING FACTOR ACTIVITY [J].

MURRAY, AW ;

SOLOMON, MJ ;

KIRSCHNER, MW .

NATURE, 1989, 339 (6222) :280-286

[84] The spindle checkpoint: Structural insights into dynamic signalling [J].

Musacchio, A ;

Hardwick, KG .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (10) :731-741

[85] Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis [J].

Nasmyth, K .

ANNUAL REVIEW OF GENETICS, 2001, 35 :673-745

[86] The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1 [J].

Oelschlaegel, T ;

Schwickart, M ;

Matos, J ;

Bogdanova, A ;

Camasses, A ;

Havlis, J ;

Shevchenko, A ;

Zachariae, W .

CELL, 2005, 120 (06) :773-788

[87] Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest [J].

Ohsumi, K ;

Koyanagi, A ;

Yamamoto, TM ;

Gotoh, T ;

Kishimoto, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (34) :12531-12536

[88] Human p55CDC/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex [J].

Ohtoshi, A ;

Maeda, T ;

Higashi, H ;

Ashizawa, S ;

Hatakeyama, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 268 (02) :530-534

[89] Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation [J].

Passmore, LA ;

Booth, CR ;

Vénien-Bryan, C ;

Ludtke, SJ ;

Fioretto, C ;

Johnson, LN ;

Chiu, W ;

Barford, D .

MOLECULAR CELL, 2005, 20 (06) :855-866

[90] Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition [J].

Passmore, LA ;

Barford, D .

EMBO REPORTS, 2005, 6 (09) :873-878

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