The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

被引：86

作者：

Biancheri, Paolo ^{[1
,2
]}

Giuffrida, Paolo ^{[1
]}

Docena, Guillermo H. ^{[3
]}

MacDonald, Thomas T. ^{[2
]}

Corazza, Gino Roberto ^{[1
]}

Di Sabatino, Antonio ^{[1
]}

机构：

[1] Univ Pavia, S Matteo Hosp, Dept Med 1, I-27100 Pavia, Italy

[2] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London, England

[3] Univ La Plata, Lab Inmunol & Fisiopatol, La Plata, Buenos Aires, Argentina

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 01期

关键词：

Celiac disease; Crohn's disease; Myofibroblast; Regulatory T cell; Smad; REGULATORY T-CELLS; HUMAN INTESTINAL MACROPHAGES; ACTIVATES LATENT TGF-BETA-1; INFLAMMATORY-BOWEL-DISEASE; FACTOR-BETA REGULATION; TGF-BETA; CELIAC-DISEASE; DENDRITIC CELLS; ANTISENSE OLIGONUCLEOTIDE; CUTTING EDGE;

D O I：

10.1016/j.cytogfr.2013.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Transforming growth factor (TGF)-beta, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-beta also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-beta signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-beta signaling in chronic intestinal diseases. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：45 / 55

页数：11

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