Advances in the management of digoxin toxicity in the older patient

Digoxin intoxication is a common problem in the elderly, In its mildest forms it may go undiagnosed, but in severe eases it is often fatal. Altered digoxin pharmacokinetics. attributable to the physiological changes associated with aging, underlying illnesses, and drug-drug interactions all contribute Co the occurrence of digoxin toxicity. Advanced agr, male gender, initial hyperkalaemia, underlying heart disease, and advanced atrioventricular block at the time of admission are peter prognostic factors. Supportive care alone is often insufficient. Digoxin-specific Fab therapy may result in dramatic recovery from digoxin intoxication, but it must be administered early and in an adequate dosage if reductions in mortality are to be achieved.