Tobacco Mosaic Virus (TMV) Inhibitors from Picrasma quassioides Benn

被引：112

作者：

Chen, Jia ^{[1
,2
]}

Yan, Xiao-Hui ^{[1
,2
]}

Dong, Jia-Hong ^{[3
,4
]}

Sang, Peng ^{[3
,4
]}

Fang, Xin ^{[1
]}

Di, Ying-Tong ^{[1
]}

Zhang, Zhong-Kai ^{[3
,4
]}

Hao, Xiao-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Yunnan Acad Agr Sci, Biotechnol & Genet Germplasm Inst, Kunming 650223, Peoples R China

[4] Key Lab Agr Biotechnol Yunnan Prov, Kunming 650223, Yunnan, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 15期

关键词：

Tobacco mosaic virus (TMV); Picrasma quassioides Benn; beta-carboline; synergistic effects; BETA-CARBOLINE ALKALOIDS; CANTHIN-6-ONE ALKALOIDS; BIOLOGICAL EVALUATION; CONSTITUENTS; PURIFICATION; DERIVATIVES; RESISTANCE; PROTEIN; TARGET; RNA;

D O I：

10.1021/jf901632j

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the beta-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.

引用

页码：6590 / 6595

页数：6

共 31 条

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