Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines

被引：68

作者：

Drag, Marcin ^{[1
]}

Surowiak, Pawel ^{[2
,3
,4
]}

Drag-Zalesinska, Malgorzata ^{[2
]}

Dietel, Manfred ^{[3
]}

Lage, Hermann ^{[3
]}

Oleksyszyn, Jozef ^{[1
]}

机构：

[1] Wroclaw Univ Technol, Div Med Chem & Microbiol, Fac Chem, PL-50370 Wroclaw, Poland

[2] Univ Sch Med, Dept Histol & Embryol, PL-50356 Wroclaw, Poland

[3] Inst Pathol, D-10117 Berlin, Germany

[4] Lower Silesian Oncol Ctr, PL-53413 Wroclaw, Poland

来源：

MOLECULES | 2009年 / 14卷 / 04期

关键词：

Betulin; Betulinic acid; Birch; Gastric carcinoma; Pancreatic carcinoma; CANCER-CELLS; PENTACYCLIC TRITERPENES; MULTIDRUG-RESISTANT; INDUCED APOPTOSIS; ABC-TRANSPORTERS; MELANOMA-CELLS; MITOXANTRONE; INHIBITION; ACTIVATION; EXPRESSION;

D O I：

10.3390/molecules14041639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer.

引用

页码：1639 / 1651

页数：13

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