Protective duration of immunity of an inactivated bluetongue (BTV) serotype 2 vaccine against a virulent BTV serotype 2 challenge in sheep

被引：21

作者：

Hamers, C. ^{[1
]}

Rehbein, S. ^{[3
]}

Hudelet, P. ^{[2
]}

Blanchet, M. ^{[1
]}

Lapostolle, B. ^{[2
]}

Cariou, C. ^{[2
]}

Duboeuf, M. ^{[2
]}

Goutebroze, S. ^{[1
]}

机构：

[1] MERIAL SAS, F-01150 St Vulbas, France

[2] MERIAL SAS, F-69007 Lyon, France

[3] MERIAL GmbH, Kathrinhof Res Farm, D-83101 Rohdorf, Germany

来源：

VACCINE | 2009年 / 27卷 / 21期

关键词：

Bluetongue virus; Inactivated vaccine; Sheep; Year protection; VIRUS-LIKE PARTICLES; NORTHERN EUROPE; UNITED-KINGDOM; EPIDEMIOLOGY; TRANSMISSION; REEMERGENCE; CULICOIDES; EFFICACY; PROTEINS; DISEASE;

D O I：

10.1016/j.vaccine.2009.02.099

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The protective properties of an inactivated bluetongue virus serotype 2 (BTV-2) vaccine were evaluated in sheep, Sheep (two groups of seven), vaccinated with either one or two doses of the vaccine. were monitored for antibody response over one year. All sheep developed high titres of neutralizing antibodies by 35 clays after first vaccination and titres were maintained over one year. Control sheep (n = 7) remained seronegative until challenge. One year after vaccination, all sheep were inoculated with a virulent BTV-2. All controls developed pyrexia, clinical signs and viraemia. In contrast, the sheep vaccinated with one or two doses of inactivated BTV-2 vaccine were protected from clinical disease and viraemia was completely prevented. These data show that a single close of the BTV-2 vaccine given to sheep induces a Strong immunity which confers protection for at least one year. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2789 / 2793

页数：5

共 47 条

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