Synthesis and biological evaluation of flavonoids as vasorelaxant agents

被引：44

作者：

Chen, ZW ^{[1
]}

Hu, YZ ^{[1
]}

Wu, HH ^{[1
]}

Jiang, HD ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Med Chem, Sch Pharmaceut Sci, Hangzhou 310031, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

5,7-dihydroxyflavone; quercetin; 3-O-glycosides; vasorelaxant activity;

D O I：

10.1016/j.bmcl.2004.05.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 5,7-dihydroxyflavone and quercetin 3-O-glycosides have been synthesized and evaluated for vasorelaxant activity. A logP-activity relationship amongst flavonoids was suggested. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3949 / 3952

页数：4

共 10 条

[1] Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta [J].

Ajay, M ;

Gilani, AUA ;

Mustafa, MR .

LIFE SCIENCES, 2003, 74 (05) :603-612

[2] Regio- and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-β-D-glucuronide [J].

Bouktaib, M ;

Atmani, A ;

Rolando, C .

TETRAHEDRON LETTERS, 2002, 43 (35) :6263-6266

[3]

Chen CK, 1996, GEN PHARMACOL-VASC S, V27, P363

[4] Flavonoids - Chemistry, metabolism, cardioprotective effects, and dietary sources [J].

Cook, NC ;

Samman, S .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1996, 7 (02) :66-76

[5] PHASE-TRANSFER-CATALYZED SYNTHESIS OF FLAVONOID GLYCOSIDES [J].

DEMETZOS, C ;

SKALTSOUNIS, AL ;

TILLEQUIN, F ;

KOCH, M .

CARBOHYDRATE RESEARCH, 1990, 207 (01) :131-137

[6] QUERCETIN GLUCOSIDES AND GALACTOSIDES - SUBSTRATES AND INHIBITORS OF APPLE BETA-GALACTOSIDASE [J].

DICK, AJ ;

SMITH, KC .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1990, 38 (04) :923-926

[7] Determination of octanol-water partition coefficient for terpenoids using reversed-phase high-performance liquid chromatography [J].

Griffin, S ;

Wyllie, SG ;

Markham, J .

JOURNAL OF CHROMATOGRAPHY A, 1999, 864 (02) :221-228

[8] Advances in flavonoid research since 1992 [J].

Harborne, JB ;

Williams, CA .

PHYTOCHEMISTRY, 2000, 55 (06) :481-504

[9]

Saxena S., 1985, SYNTHESIS-STUTTGART, P697

[10]

Zhou Jie, 2002, Zhejiang Da Xue Xue Bao Yi Xue Ban, V31, P410

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