HPLC method for determination of cefuroxime in plasma

被引：8

作者：

Piva, G ^{[1
]}

Farin, D ^{[1
]}

Gozlan, I ^{[1
]}

Kitzes-Cohen, R ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Carmel Med Ctr, Clin Pharmacol & Infect Dis Unit, IL-31096 Haifa, Israel

来源：

CHROMATOGRAPHIA | 2000年 / 51卷 / 3-4期

关键词：

column liquid chromatography; cefuroxime in human plasma; solid phase extration;

D O I：

10.1007/BF02490557

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes an HPLC method for the determination of cefuroxime in human plasma. The method uses solid phase extraction (SPE) and has acceptable sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.1 mu g mL(-1). Calibration curves were linear within 0.1-20 mu g mL(-1), with mean correlation coefficient of 0.9982. Mean inter day precision and accuracy were 7.8 % and 6.4 %, respectively. The method was applied to determine cefuroxime levels in patients receiving cefuroxime, 3 time per day.

引用

页码：154 / 156

页数：3

共 7 条

[1]

GOODWIN CS, 1977, J ANTIMICROB CHEMOTH, V3, P253, DOI 10.1093/jac/3.3.253

[2] CONCENTRATION OF CEFUROXIME IN SERUM AND MIDDLE-EAR EFFUSION AFTER SINGLE DOSE TREATMENT WITH CEFUROXIME AXETIL [J].