Proteasome and myogenesis

被引：23

作者：

Gardrat, F ^{[1
]}

Montel, V ^{[1
]}

Raymond, J ^{[1
]}

Azanza, JL ^{[1
]}

机构：

[1] UNIV BORDEAUX 1,ENSSTAB,LAB BIOCHIM & TECHNOL ALIMENTS URA INRA,F-33405 TALENCE,FRANCE

来源：

MOLECULAR BIOLOGY REPORTS | 1997年 / 24卷 / 1-2期

关键词：

antisense oligodesoxyribonucleotide; inhibitors; myoblast culture; myogenesis; proteasome; ubiquitin;

D O I：

10.1023/A:1006877214153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report, we examine the involvement of the ubiquitin-proteasome pathway during fusion and differentiation of myoblast primary cell cultures. Up-regulation of proteasome was observed at the maximum fusion rate and was preceded by an increase of unidentified ubiquitin-conjugates. Cell permeable proteasome inhibitors prevent fusion as do antisense oligodesoxyribonucleotides targetted to three proteasome subunits. Identical results were obtained using E3 ubiquitin-ligases dipeptide inhibitor. Involvement of the ubiquitin-proteasome pathway in the regulation of myogenic factors was hypothetized.

引用

页码：77 / 81

页数：5

共 29 条

[1]

BALCERZAK D, 1995, J CELL SCI, V108, P2077

[2]

BRUSTIS JJ, 1994, EUR J CELL BIOL, V64, P320

[3] CA2+-DEPENDENT PROTEINASES (CALPAINS) AND MUSCLE-CELL DIFFERENTIATION [J].

COTTIN, P ;

BRUSTIS, JJ ;

POUSSARD, S ;

ELAMRANI, N ;

BRONCARD, S ;

DUCASTAING, A .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1994, 1223 (02) :170-178

[4] p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts [J].

Dietrich, C ;

Bartsch, T ;

Schanz, F ;

Oesch, F ;

Wieser, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :10815-10819

[5] Desmin degradation and Ca2+-dependent proteolysis during myoblast fusion [J].

Elamrani, N ;

Brustis, JJ ;

Dourdin, N ;

Balcerzak, D ;

Poussard, S ;

Cottin, P ;

Ducastaing, A .

BIOLOGY OF THE CELL, 1995, 85 (2-3) :177-183

[6] A NOVEL CHYMOTRYPSIN-LIKE COMPONENT OF THE MULTICATALYTIC PROTEINASE COMPLEX OPTIMALLY ACTIVE AT ACIDIC PH [J].

FIGUEIREDOPEREIRA, ME ;

CHEN, WE ;

YUAN, HM ;

WILK, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 317 (01) :69-78

[7] FUNCTIONS OF THE PROTEASOME - THE LYSIS AT THE END OF THE TUNNEL [J].

GOLDBERG, AL .

SCIENCE, 1995, 268 (5210) :522-523

[8] INTERACTION OF MYOGENIC FACTORS AND THE RETINOBLASTOMA PROTEIN MEDIATES MUSCLE-CELL COMMITMENT AND DIFFERENTIATION [J].

GU, W ;

SCHNEIDER, JW ;

CONDORELLI, G ;

KAUSHAL, S ;

MAHDAVI, V ;

NADALGINARD, B .

CELL, 1993, 72 (03) :309-324

[9]

GUO K, 1995, MOL CELL BIOL, V15, P3823

[10] CORRELATION OF TERMINAL CELL-CYCLE ARREST OF SKELETAL-MUSCLE WITH INDUCTION OF P21 BY MYOD [J].

HALEVY, O ;

NOVITCH, BG ;

SPICER, DB ;

SKAPEK, SX ;

RHEE, J ;

HANNON, GJ ;

BEACH, D ;

LASSAR, AB .

SCIENCE, 1995, 267 (5200) :1018-1021

← 1 2 3 →