Proteasome and myogenesis

被引：23

作者：

Gardrat, F ^{[1
]}

Montel, V ^{[1
]}

Raymond, J ^{[1
]}

Azanza, JL ^{[1
]}

机构：

[1] UNIV BORDEAUX 1,ENSSTAB,LAB BIOCHIM & TECHNOL ALIMENTS URA INRA,F-33405 TALENCE,FRANCE

来源：

MOLECULAR BIOLOGY REPORTS | 1997年 / 24卷 / 1-2期

关键词：

antisense oligodesoxyribonucleotide; inhibitors; myoblast culture; myogenesis; proteasome; ubiquitin;

D O I：

10.1023/A:1006877214153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report, we examine the involvement of the ubiquitin-proteasome pathway during fusion and differentiation of myoblast primary cell cultures. Up-regulation of proteasome was observed at the maximum fusion rate and was preceded by an increase of unidentified ubiquitin-conjugates. Cell permeable proteasome inhibitors prevent fusion as do antisense oligodesoxyribonucleotides targetted to three proteasome subunits. Identical results were obtained using E3 ubiquitin-ligases dipeptide inhibitor. Involvement of the ubiquitin-proteasome pathway in the regulation of myogenic factors was hypothetized.

引用

页码：77 / 81

页数：5

共 29 条

[21] Control of gene expression by proteolysis [J].

Pahl, HL ;

Baeuerle, PA .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (03) :340-347

[22] THE UBIQUITIN-PROTEASOME PATHWAY IS REQUIRED FOR PROCESSING THE NF-KAPPA-B1 PRECURSOR PROTEIN AND THE ACTIVATION OF NF-KAPPA-B [J].

PALOMBELLA, VJ ;

RANDO, OJ ;

GOLDBERG, AL ;

MANIATIS, T .

CELL, 1994, 78 (05) :773-785

[23] P53-INDEPENDENT EXPRESSION OF P21(CIP)1 IN MUSCLE AND OTHER TERMINALLY DIFFERENTIATING CELLS [J].

PARKER, SB ;

EICHELE, G ;

ZHANG, PM ;

RAWLS, A ;

SANDS, AT ;

BRADLEY, A ;

OLSON, EN ;

HARPER, JW ;

ELLEDGE, SJ .

SCIENCE, 1995, 267 (5200) :1024-1027

[24] Interference with p53 protein inhibits hematopoietic and muscle differentiation [J].

Soddu, S ;

Blandino, G ;

Scardigli, R ;

Coen, S ;

Marchetti, A ;

Rizzo, MG ;

Bossi, G ;

Cimino, L ;

Crescenzi, M ;

Sacchi, A .

JOURNAL OF CELL BIOLOGY, 1996, 134 (01) :193-204

[25]

TAKADA K, 1995, MOL BIOL REP, V21, P21

[26] MOLECULAR-CLONING OF CDNAS FOR RAT PROTEASOMES - DEDUCED PRIMARY STRUCTURES OF 4 OTHER SUBUNITS [J].

TAMURA, T ;

SHIMBARA, N ;

AKI, M ;

ISHIDA, N ;

BEY, F ;

SCHERRER, K ;

TANAKA, K ;

ICHIHARA, A .

JOURNAL OF BIOCHEMISTRY, 1992, 112 (04) :530-534

[27] MOLECULAR-CLONING OF CDNA FOR PROTEASOMES FROM RAT-LIVER - PRIMARY STRUCTURE OF COMPONENT-C3 WITH A POSSIBLE TYROSINE PHOSPHORYLATION SITE [J].

TANAKA, K ;

FUJIWARA, T ;

KUMATORI, A ;

SHIN, S ;

YOSHIMURA, T ;

ICHIHARA, A ;

TOKUNAGA, F ;

ARUGA, R ;

IWANAGA, S ;

KAKIZUKA, A ;

NAKANISHI, S .

BIOCHEMISTRY, 1990, 29 (15) :3777-3785

[28] PURIFICATION AND CHARACTERIZATION OF A Z-LEU-LEU-LEU-MCA DEGRADING PROTEASE EXPECTED TO REGULATE NEURITE FORMATION - A NOVEL CATALYTIC ACTIVITY IN PROTEASOME [J].

TSUBUKI, S ;

KAWASAKI, H ;

SAITO, Y ;

MIYASHITA, N ;

INOMATA, M ;

KAWASHIMA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (03) :1195-1201

[29] Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation [J].

Wang, J ;

Walsh, K .

SCIENCE, 1996, 273 (5273) :359-361

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