Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae

被引：14

作者：

Furukawa, Y

Kawakami, T

Sudo, K

Inazawa, J

Matsumine, A

Akiyama, T

Nakamura, Y

机构：

[1] UNIV TOKYO, INST MED SCI, MOLEC MED LAB, MINATO KU, TOKYO 108, JAPAN

[2] UNIV TOKYO, DEPT SURG 1, TOKYO, JAPAN

[3] KYOTO PREFECTURAL UNIV MED, DEPT HYG, KYOTO 602, JAPAN

[4] OSAKA UNIV, MICROBIAL DIS RES INST, DEPT ONCOGENE RES, OSAKA, JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 73卷 / 1-2期

关键词：

D O I：

10.1159/000134323

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have isolated a novel human gene RPD3L1, that is highly homologous to a transcription factor in Saccharomyces cerevisiae, RPD3 (reduced potassium dependency 3), from a human fetal lung cDNA library. The cDNA clone, hRPD3, consists of 2,100 nucleotides that contain an open reading frame of 1446 nucleotides encoding 482 amino acids. it shares 62% identity in nucleotide sequence and 52% identity in amino acid sequence to RPD3. This gene is expressed at various levels in all tissues examined. Furthermore, we were able to map it to chromosome band 1p34.1 by FISH.

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页码：130 / 133

页数：4

相关论文

共 25 条

[1] IDENTIFICATION OF A HIGHLY CONSERVED 3' UTR IN THE TRANSLATIONALLY REGULATED MESSENGER-RNA FOR PROSTAGLANDIN SYNTHASE [J].

BAILEY, JM ;

VERMA, M .

PROSTAGLANDINS, 1990, 40 (06) :585-590

[2] SELECTIVE-INHIBITION OF ACTIVATED BUT NOT BASAL TRANSCRIPTION BY THE ACIDIC ACTIVATION DOMAIN OF VP16 - EVIDENCE FOR TRANSCRIPTIONAL ADAPTERS [J].

BERGER, SL ;

CRESS, WD ;

CRESS, A ;

TRIEZENBERG, SJ ;

GUARENTE, L .

CELL, 1990, 61 (07) :1199-1208

[3] MOLECULAR-BASIS OF MYOTONIC-DYSTROPHY - EXPANSION OF A TRINUCLEOTIDE (CTG) REPEAT AT THE 3' END OF A TRANSCRIPT ENCODING A PROTEIN-KINASE FAMILY MEMBER [J].

BROOK, JD ;

MCCURRACH, ME ;

HARLEY, HG ;

BUCKLER, AJ ;

CHURCH, D ;

ABURATANI, H ;

HUNTER, K ;

STANTON, VP ;

THIRION, JP ;

HUDSON, T ;

SOHN, R ;

ZEMELMAN, B ;

SNELL, RG ;

RUNDLE, SA ;

CROW, S ;

DAVIES, J ;

SHELBOURNE, P ;

BUXTON, J ;

JONES, C ;

JUVONEN, V ;

JOHNSON, K ;

HARPER, PS ;

SHAW, DJ ;

HOUSMAN, DE .

CELL, 1992, 68 (04) :799-808

[4] TRANSCRIPTION FACTOR INTERACTIONS - SELECTORS OF POSITIVE OR NEGATIVE REGULATION FROM A SINGLE DNA ELEMENT [J].

DIAMOND, MI ;

MINER, JN ;

YOSHINAGA, SK ;

YAMAMOTO, KR .

SCIENCE, 1990, 249 (4974) :1266-1272

[5] THE SACCHAROMYCES-CEREVISIAE SPT13 GAL11 GENE HAS BOTH POSITIVE AND NEGATIVE REGULATORY ROLES IN TRANSCRIPTION [J].

FASSLER, JS ;

WINSTON, F .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (12) :5602-5609

[6] NEGATIVE EFFECT OF THE TRANSCRIPTIONAL ACTIVATOR GAL4 [J].

GILL, G ;

PTASHNE, M .

NATURE, 1988, 334 (6184) :721-724

[7] DIDEOXY SEQUENCING METHOD USING DENATURED PLASMID TEMPLATES [J].

HATTORI, M ;

SAKAKI, Y .

ANALYTICAL BIOCHEMISTRY, 1986, 152 (02) :232-238

[8] THE REGULATION OF TRANSCRIPTION BY PHOSPHORYLATION [J].

HUNTER, T ;

KARIN, M .

CELL, 1992, 70 (03) :375-387

[9] PHYSICAL ORDERING OF 3 POLYMORPHIC DNA MARKERS SPANNING THE REGIONS CONTAINING A TUMOR SUPPRESSOR GENE OF RENAL-CELL CARCINOMA BY 3-COLOR FLUORESCENT INSITU HYBRIDIZATION [J].

INAZAWA, J ;

ARIYAMA, T ;

ABE, T .

JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (12) :1248-1252

[10] NUCLEOLAR TRANSCRIPTION FACTOR HUBF CONTAINS A DNA-BINDING MOTIF WITH HOMOLOGY TO HMG PROTEINS [J].

JANTZEN, HM ;

ADMON, A ;

BELL, SP ;

TJIAN, R .

NATURE, 1990, 344 (6269) :830-836