Candida rugosa lipase: Enantioselectivity enhancements in organic solvents

被引：28

作者：

Persichetti, RA ^{[1
]}

Lalonde, JJ ^{[1
]}

Govardhan, CP ^{[1
]}

Khalaf, NK ^{[1
]}

Margolin, AL ^{[1
]}

机构：

[1] ALTUS BIOL,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 36期

关键词：

D O I：

10.1016/0040-4039(96)01430-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral resolutions of carboxylic acids (1-3) and alcohol (4) were carried out through esterification or transesterification in organic solvents using cross-linked enzyme crystals (CLEC(R)) of Candida rugosa lipase (CRL). Comparison of these results with those of elude CRL reveal significant differences. As was seen in resolution through hydrolysis,(1) a marked improvement in enantioselectivity is realized with the CLEC. Additionally, the stability afforded the enzyme in CLEC form leads to a higher activity in organic solvent. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6507 / 6510

页数：4

共 27 条

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