Stem cells in the treatment of Parkinson's disease

被引：90

作者：

Arenas, E ^{[1
]}

机构：

[1] Karolinska Inst, MBB, Mol Neurobiol Lab, S-17177 Stockholm, Sweden

来源：

BRAIN RESEARCH BULLETIN | 2002年 / 57卷 / 06期

关键词：

nurr1; GDNF; dopamine; development; induction; differentiation;

D O I：

10.1016/S0361-9230(01)00772-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stem cells have been suggested as candidate therapeutic tools for neurodegenerative disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In this review I summarize some of the evidence currently available concerning two approaches for the treatment of Parkinson's disease: (1) The generation of dopaminergic neurons from embryonic stem cells, multipotent stem cells, and neuronal progenitor cells for cell replacement therapy. (2) The engineering of multipotent stem cells to release glial cell-line derived neurotrophic factor, a potent neurotrophic factor for dopaminergic neurons, in a neuroprotective and neuroregenerative approach to the treatment of Parkinson's disease. (C) 2002 Elsevier Science Inc.

引用

收藏

页码：795 / 808

页数：14

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