New dimeric macrolide glycosides from the marine sponge Myriastra clavosa

被引：53

作者：

Erickson, KL ^{[1
]}

Gustafson, KR ^{[1
]}

Pannell, LK ^{[1
]}

Beutler, JA ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21701 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1021/np020193z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Clavosolides A-D (1-4), dimeric macrolides incorporating cyclopropyl, tetrahydropyranyl, and glycosidic ring systems, were isolated from the cytotoxic extract of a Philippines collection of the marine sponge Myriastra clavosa. The structures of the clavosolides, which occurred as only trace metabolites, were elucidated through extensive NMR spectroscopic analyses. Clavosolides A (1) and B (2) were recently reported metabolites from M. clavosa, while the unsymmetrical dimers clavosolides C (3) and D (4) had new structures.

引用

页码：1303 / 1306

页数：4

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