Clavosines A-C from the marine sponge Myriastra clavosa:: Potent cytotoxins and inhibitors of protein phosphatases 1 and 2A

被引：33

作者：

Fu, X

Schmitz, FJ ^{[1
]}

Kelly-Borges, M

McCready, TL

Holmes, CFB

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

[2] Fac Hlth Sci & Technol, UNITEC Inst Technol, Auckland, New Zealand

[3] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 22期

关键词：

D O I：

10.1021/jo981249q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Clavosines A (1) and B (2), novel metabolites closely related to calyculins and calyculinamides, have been isolated from the marine sponge Myriastra clavosa. Clavosine C (3) was also isolated and is assumed to be an artifact from clavosine B (2). Structures of these compounds were determined by spectroscopic analysis and by comparison of their NMR data with those of the calyculins and calyculinamides. Clavosines A and B were found to be very potent cytotoxins in the National Cancer Institute's screening panel of 60 tumor cell lines and were potent inhibitors of the type 1 and 2A serine/threonine protein phosphatases.

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页码：7957 / 7963

页数：7

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