Thyroid hormone transporters: recent advances

被引：83

作者：

Abe, T ^{[1
]}

Suzuki, T

Unno, M

Tokui, T

Ito, S

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Med, Div Nephrol Endocrinol & Vasc Med, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Surg, Div Gastroenterol Surg,Aoba Ku, Sendai, Miyagi 9808574, Japan

[3] Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo 140, Japan

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1016/S1043-2760(02)00599-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid hormones, being hydrophobic, were thought to enter target cell membranes by passive diffusion. However, recent studies have documented the existence of numerous organic anion transport systems, about half of which also transport thyroid hormones into (and possibly out of) a variety of target cells. Several of the genes encoding thyroid hormone transporters have been characterized by means of molecular approaches. Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are.

引用

页码：215 / 220

页数：6

共 60 条

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