Nuclear actin and actin-related proteins in chromatin remodeling

被引:341
作者
Olave, IA [1 ]
Reck-Peterson, SL
Crabtree, GR
机构
[1] Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Howard Hughes Med Inst, Dept Pathol, Stanford, CA 94305 USA
关键词
SWI/SNF; BAF; tumor suppressor; chromatin; Arps;
D O I
10.1146/annurev.biochem.71.110601.135507
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The existence and function of actin in the nucleus has been hotly debated for forty years. Recently, beta-actin was found to be a component of mammalian SWI/SNF-like BAF chromatin remodeling complexes and still more recently other SWI/SNF-related chromatin remodeling complexes in yeast, flies, and man. Although the function of actin in these chromatin remodeling complexes is only starting to be explored, the fact that actin is one of the most regulated proteins in the cell suggests that control of nuclear actin may be a critical regulatory point in the control of chromatin remodeling. Actin rapidly shuttles between the nucleus and the cytoplasm offering additional sites and modes of regulation. In addition, actin-related proteins (Arps) are also components of these chromatin remodeling complexes and have been implicated in transcriptional control in yeast. The observation that the BAF chromatin remodeling complex in which actin was originally identified, is also a human tumor suppressor complex necessary for the actions of the retinoblastoma protein indicates that the study of nuclear actin is likely to contribute to understanding cell growth control.
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页码:755 / 781
页数:27
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