Controlling the elongation phase of transcription with P-TEFb

被引:888
作者
Peterlin, B. Matija [1 ]
Price, David H.
机构
[1] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA
[2] Univ Calif San Francisco, Rosalind Russell Med Res Ctr, Dept Med Microbiol & Immunol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/j.molcel.2006.06.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The positive transcription elongation factor b(P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.
引用
收藏
页码:297 / 305
页数:9
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