Intracellular calcium releases facilitate induction of long-term depression

被引：8

作者：

Kato, N ^{[1
]}

Isomura, Y ^{[1
]}

Tanaka, T ^{[1
]}

机构：

[1] Kyoto Univ, Sch Med, Dept Integrat Brain Sci, Kyoto 6068501, Japan

来源：

NEUROPHARMACOLOGY | 2000年 / 39卷 / 06期

关键词：

synaptic plasticity; neocortex; calcium release; caged IP3; long-term potentiation; long-term depression;

D O I：

10.1016/S0028-3908(99)00234-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Visual cortex layer II/III pyramidal neurons, lone-term depression (LTD) of synaptic currents was induced by a combination of the intracellular increase of inositol-1,4,5-trisphosphate (IP3), achieved by photolyzing caged-IP3, and the tetanization to nearby cortex, but not by either of these two procedures alone. A facilitatory role of an IP3-induced calcium release in LTD is suggested. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1107 / 1110

页数：4

共 13 条

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