Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

被引：87

作者：

Chopp, Michael ^{[1
,2
]}

Li, Yi

Zhang, Zheng Gang

机构：

[1] Henry Ford Hosp, Dept Neurol, Div Res, Detroit, MI 48202 USA

[2] Oakland Univ, Rochester, MI 48063 USA

来源：

STROKE | 2009年 / 40卷 / 03期

关键词：

stroke; cell-based therapies; mechanisms; neurological function; MARROW STROMAL CELL; ENDOTHELIAL-CELLS; ANGIOGENESIS; RATS; NEUROGENESIS; EXPRESSION; BRAIN;

D O I：

10.1161/STROKEAHA.108.533141

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We discuss the mechanisms of action underlying the beneficial effects of treating ischemic stroke in the rodent with exogenously administered cells. The essential hypothesis proposed is that the administered cells enhance recovery of neurological function by stimulating the production of restorative factors by parenchymal cells. These activated endogenous brain cells evoke white matter remodeling in the brain and the spinal cord and generate microenvironments within the injured brain that amplify brain plasticity and lead to improvement in neurological function poststroke. (Stroke. 2009; 40[suppl 1]: S143-S145.)

引用

页码：S143 / S145

页数：3

共 15 条

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SHEN L, GLIA IN PRESS

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