Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

被引:56
作者
Kloog, Y [1 ]
Cox, AD
机构
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
[2] Univ N Carolina, Sch Med, Dept Radiat Oncol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Sch Med, Dept Pharmacol, Chapel Hill, NC 27599 USA
关键词
Ras; Rho; farnesyl; geranylgeranyl; galectin-1;
D O I
10.1016/j.semcancer.2004.04.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ras and Rho GTPases are prominent participants in malignant transformation. They possess an essential prenyl group (farnesyl or geranylgeranyl) that endows them with membrane-tethering ability and functional specificity. Accumulating evidence suggests that prenyl groups are involved primarily in lipid-protein interactions, and recent experiments point to prenyl-binding hydrophobic pockets in proteins regulating Ras and Rho in normal cells and cancer cells. This review presents the evidence for such prenyl-binding domains as significant players in the control of Ras-like GTPases, and the emerging concept of prenyl-binding domains as potential targets for Ras inhibitors and anti-cancer drugs. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码:253 / 261
页数:9
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