Strategies for targeting complement inhibitors in ischaemia/reperfusion injury

被引：33

作者：

Dong, J

Pratt, JR ^{[1
]}

Smith, RAG

Dodd, I

Sacks, SH

机构：

[1] Univ London Kings Coll, Guys Hosp, Dept Nephrol & Transplantat, London SE1 9RT, England

[2] AdProTech PLC, Royston SG8 5HD, Herts, England

来源：

MOLECULAR IMMUNOLOGY | 1999年 / 36卷 / 13-14期

关键词：

complement; regulation; ischaemia/reperfusion;

D O I：

10.1016/S0161-5890(99)00118-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A transplanted organ suffers inherently from an ischaemic insult and subsequent reperfusion injury. The severity of such early events is thought to influence the success of the transplant procedure, not only in the immediate post-transplant period, but also to predispose the graft to both acute and chronic rejection. In this paper, we review the influence of the complement system upon ischaemia/reperfusion injury. The recognition of the involvement of complement has led to novel strategies to try to modulate ischaemia/reperfusion injury, some of which we have summarized. Finally, we note our own strategy to target complement inhibition in ischaemic tissues. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：957 / 963

页数：7

共 46 条

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