Connective tissue growth factor: a novel player in tissue reorganization after brain injury?

被引：56

作者：

Hertel, M

Tretter, Y

Alzheimer, C

Werner, S ^{[1
]}

机构：

[1] ETH Honggerberg, Inst Cell Biol, CH-8093 Zurich, Switzerland

[2] Univ Munich, Inst Physiol, D-8000 Munich, Germany

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2000年 / 12卷 / 01期

关键词：

collagen; fibronectin; hippocampus; kainic acid; mouse;

D O I：

10.1046/j.1460-9568.2000.00930.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have suggested a role of connective tissue growth factor (CTGF) in repair processes of the skin as well as in various types of fibrotic disease. However, a function of this molecule in central nervous system (CNS) repair has not been demonstrated yet. In this study we analysed the temporal and spatial expression pattern of CTGF after unilateral kainic acid lesions of the hippocampal CA3 region in mice. We found a strong induction of CTGF mRNA and protein expression in neurons and glial cells of the lesioned hippocampus. Interestingly, increased expression of this mitogen was accompanied by elevated levels of the extracellular matrix molecule fibronectin, which is a known target of CTGF action. Therefore, our data indicate a novel function of CTGF in postlesional restructuring of the hippocampus, where it possibly participates in glial scar formation.

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收藏

页码：376 / 380

页数：5

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