Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species

被引：94

作者：

Endo, T

Tsuda, M

Okada, T

Mitsuhashi, S

Shima, H

Kikuchi, K

Mikami, Y

Fromont, J

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Hokkaido Univ, Inst Med Genet, Sapporo, Hokkaido 0600815, Japan

[3] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 2600856, Japan

[4] Western Australian Museum, Perth, WA 6000, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 08期

关键词：

D O I：

10.1021/np034077n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new dimeric bromopyrrole alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10 dihydrokeramadine (9), have been isolated from the Okinawan marine sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein phosphatase 2A activity.

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页码：1262 / 1267

页数：6

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