A chemoenzymatic approach towards moenomycin structural analogues

被引：15

作者：

Range, G

Krahmer, R

Welzel, P

Muller, D

Herrmann, GF

Kragl, U

Wandrey, C

Markus, A

vanHeijenoort, Y

vanHeijenoort, J

机构：

[1] UNIV LEIPZIG, INST ORGAN CHEM, D-04103 LEIPZIG, GERMANY

[2] RUHR UNIV BOCHUM, FAK CHEM, D-44780 BOCHUM, GERMANY

[3] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST BIOTECHNOL, D-52425 JULICH, GERMANY

[4] HOECHST AG, D-65926 FRANKFURT, GERMANY

[5] UNIV PARIS 11, F-91405 ORSAY, FRANCE

来源：

TETRAHEDRON | 1997年 / 53卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(96)01116-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trisaccharide moenomycin analogue 1c has been synthesized. One starting material was N-acetyllactosamine obtained by an enzyme-catalyzed transglycosylation. 1c differs from moenomycin degradation product 1a only in two positions of unit C. In contrast to 1a the synthetic 1c is antibiotically inactive. (C) 1997, Elsevier Science Ltd.

引用

页码：1695 / 1706

页数：12

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