A STRUCTURALLY AND BIOGENETICALLY INTERESTING MOENOMYCIN ANTIBIOTIC

被引：42

作者：

DONNERSTAG, A

MARZIAN, S

MULLER, D

WELZEL, P

BOTTGER, D

STARK, A

FEHLHABER, HW

MARKUS, A

VANHEIJENOORT, Y

VANHEIJENOORT, J

机构：

[1] RUHR UNIV BOCHUM,FAK CHEM,D-44780 BOCHUM,GERMANY

[2] UNIV LEIPZIG,INST ORGAN CHEM,D-04103 LEIPZIG,GERMANY

[3] HOECHST AG,D-65926 FRANKFURT,GERMANY

[4] UNIV PARIS 11,F-91405 ORSAY,FRANCE

来源：

TETRAHEDRON | 1995年 / 51卷 / 07期

关键词：

D O I：

10.1016/0040-4020(94)01074-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isolation and structure elucidation of a new moenomycin antibiotic (A(12), 1a) is reported that differs from moenomycin A by lack of the branching methyl group and by the configuration at C-4 of unit F. The smallest antibiotically active degradation product of 1a is the trisaccharide derivative 3a. This observation is in contrast to structure activity relations in the moenomycin A series where it was found that disaccharide 4b is fully active. An explanation is offered for this difference.

引用

页码：1931 / 1940

页数：10

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