Miniature bioreactors: current practices and future opportunities

被引：196

作者：

Betts, Jonathan I. ^{[1
]}

Baganz, Frank ^{[1
]}

机构：

[1] UCL, Adv Ctr Biochem Engn, Dept Biochem Engn, London WC1E 7JE, England

来源：

MICROBIAL CELL FACTORIES | 2006年 / 5卷 / 1期

关键词：

D O I：

10.1186/1475-2859-5-21

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review focuses on the emerging field of miniature bioreactors (MBRs), and examines the way in which they are used to speed up many areas of bioprocessing. MBRs aim to achieve this acceleration as a result of their inherent high-throughput capability, which results from their ability to perform many cell cultivations in parallel. There are several applications for MBRs, ranging from media development and strain improvement to process optimisation. The potential of MBRs for use in these applications will be explained in detail in this review. MBRs are currently based on several existing bioreactor platforms such as shaken devices, stirred-tank reactors and bubble columns. This review will present the advantages and disadvantages of each design together with an appraisal of prototype and commercialised devices developed for parallel operation. Finally we will discuss how MBRs can be used in conjunction with automated robotic systems and other miniature process units to deliver a fully-integrated, high-throughput (HT) solution for cell cultivation process development.

引用

页数：14

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