Active killing of neurons during development and following stress:: a role for p75NTR and Fas?

被引：88

作者：

Raoul, C ^{[1
]}

Pettmann, B ^{[1
]}

Henderson, CE ^{[1
]}

机构：

[1] Univ Mediterranee, INSERM, CNRS, Dev Biol Inst Marseille,U382, F-13288 Marseille 09, France

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(99)00055-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evidence for active triggering of neuronal death continues to accumulate. The transmembrane receptors p75(NTR) and Fas can trigger (and in some cases are required for) programmed cell death of the neurons that express them, through signalling pathways that are regulated by a variety of cytoplasmic effecters. Neuronal death induced by trophic deprivation often requires Fas signalling, further blurring the boundaries between naturally occurring and stress-induced neuronal death.

引用

页码：111 / 117

页数：7

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