Intravitreal Anakinra Inhibits Choroidal Neovascular Membrane Growth in a Rat Model

被引：38

作者：

Olson, Jeffrey L. ^{[1
]}

Courtney, Robert J. ^{[1
]}

Rouhani, Behnaz ^{[1
]}

Mandava, Naresh ^{[1
]}

Dinarello, Charles A. ^{[1
]}

机构：

[1] Univ Colorado, Denver, CO 80202 USA

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2009年 / 17卷 / 03期

关键词：

anakinra; angiogenesis; choroidal neovascularization; interleukin-1; macular degeneration; BLOOD-RETINAL BARRIER; MACULAR DEGENERATION; SYNOVIAL FIBROBLASTS; FACTOR VEGF; IN-VIVO; INTERLEUKIN-1; EXPRESSION; SUPPRESSION; IL-1; TRIAMCINOLONE;

D O I：

10.1080/09273940802710705

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model. Methods: Laser photocoagulation used to rupture Bruch's membrane; animals then assigned to groups based on varying frequency of intravitreal anakinra injections. At day 30, digital angiography was used to measure the CNV area. Result: Intravitreal anakinra dose-dependently inhibited CNV growth. Injections given one time resulted in a 26% reduction in CNV; in the once weekly group, a 41% reduction was seen; in the twice-weekly group, a 62% reduction was seen (all p .001). Conclusion: Suppressing IL-1 function may provide another therapeutic avenue in exudative AMD.

引用

收藏

页码：195 / 200

页数：6

相关论文

共 39 条

[1] INCREASED VASCULAR ENDOTHELIAL GROWTH-FACTOR LEVELS IN THE VITREOUS OF EYES WITH PROLIFERATIVE DIABETIC-RETINOPATHY [J].

ADAMIS, AP ;

MILLER, JW ;

BERNAL, MT ;

DAMICO, DJ ;

FOLKMAN, J ;

YEO, TK ;

YEO, KT .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 118 (04) :445-450

[2] SUPPRESSION OF RETINAL NEOVASCULARIZATION IN-VIVO BY INHIBITION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) USING SOLUBLE VEGF-RECEPTOR CHIMERIC PROTEINS [J].

AIELLO, LP ;

PIERCE, EA ;

FOLEY, ED ;

TAKAGI, H ;

CHEN, H ;

RIDDLE, L ;

FERRARA, N ;

KING, GL ;

SMITH, LEH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10457-10461

[3] VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].

AIELLO, LP ;

AVERY, RL ;

ARRIGG, PG ;

KEYT, BA ;

JAMPEL, HD ;

SHAH, ST ;

PASQUALE, LR ;

THIEME, H ;

IWAMOTO, MA ;

PARK, JE ;

NGUYEN, HV ;

AIELLO, LM ;

FERRARA, N ;

KING, GL .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487

[4]

Amin ARMR, 2003, INT J ONCOL, V23, P1727

[5] TGF-beta1, IL-1beta, and Th2 cytokines stimulate vascular endothelial growth factor production from conjunctival fibroblasts [J].

Asano-Kato, N ;

Fukagawa, K ;

Okada, N ;

Kawakita, T ;

Takano, Y ;

Dogru, M ;

Tsubota, K ;

Fujishima, H .

EXPERIMENTAL EYE RESEARCH, 2005, 80 (04) :555-560

[6] A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development [J].

Bar, D ;

Apte, RN ;

Voronov, E ;

Dinarello, CA ;

Cohen, S .

FASEB JOURNAL, 2004, 18 (01) :161-163

[7] INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION IN SYNOVIAL FIBROBLASTS BY PROSTAGLANDIN-E AND INTERLEUKIN-1 - A POTENTIAL MECHANISM FOR INFLAMMATORY ANGIOGENESIS [J].

BENAV, P ;

CROFFORD, LJ ;

WILDER, RL ;

HLA, T .

FEBS LETTERS, 1995, 372 (01) :83-87

[8] Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein [J].

Biswas, PS ;

Banerjee, K ;

Zheng, M ;

Rouse, BT .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (04) :868-875

[9] Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: Possible role for IL-1 in herpetic stromal keratitis pathogenesis [J].

Biswas, PS ;

Banerjee, K ;

Kim, B ;

Rouse, BT .

JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3736-3744

[10] Constitutive repression of interleukin-1α in endothelial cells [J].

Brunn, Gregory J. ;

Saadi, Soheyla ;

Platt, Jeffrey L. .

CIRCULATION RESEARCH, 2008, 102 (07) :823-830

← 1 2 3 4 →