Viral inhibition of interferon signal transduction

被引:49
作者
Cebulla, CM [1 ]
Miller, DM [1 ]
Sedmak, DD [1 ]
机构
[1] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA
关键词
adenovirus; cytomegalovirus; Ebola virus; Epstein-Barr virus; hepatitis B virus; human papilloma virus; interferon signal transduction; mumps; varicella-zoster virus; JAK/STAT pathway;
D O I
10.1159/000053968
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The type I and II interferons (IFNs) are potent stimulators of antigen processing and presentation and are essential in antiviral immunity. IFNs upregulate the transcription of major histocompatibility complex (MHC) class I and II molecules, associated antigen-processing proteins, and induce the production of direct antiviral effector molecules such as 2',5'-oligoadenylate synthetase, double-stranded-RNA-dependent protein kinase and Mr proteins. It is increasingly evident that viruses have evolved mechanisms to globally inhibit the actions of IFNs through disruption of their signal transduction pathways. Herein, we review the ability and novel mechanisms of several diverse viruses to inhibit IFN-induced JAK/STAT signal transduction. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:325 / 330
页数:6
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