Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup

被引：11

作者：

Paul, Bishwajit

Bajaj, Avinash

Indi, S. S.

Bhattacharya, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 47期

关键词：

dimeric lipids; vesicles; gene transfer;

D O I：

10.1016/j.tetlet.2006.09.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8401 / 8405

页数：5

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