In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy

被引:131
作者
Amelink, A
Sterenborg, HJCM
Bard, MPL
Burgers, SA
机构
[1] Erasmus Med Ctr, Dept Radiat Oncol, NL-3008 AE Rotterdam, Netherlands
[2] Erasmus Sch Ctr, Dept Pulm Dis, NL-3008 AE Rotterdam, Netherlands
关键词
D O I
10.1364/OL.29.001087
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue in vivo. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our data collected to date show that cancerous bronchial mucosa has a lower capillary oxygenation and a larger average capillary diameter than normal bronchial mucosa. (C) 2004 Optical Society of America
引用
收藏
页码:1087 / 1089
页数:3
相关论文
共 22 条
  • [1] Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media
    Amelink, A
    Bard, MPL
    Burgers, SA
    Sterenborg, HJCM
    [J]. APPLIED OPTICS, 2003, 42 (19) : 4095 - 4101
  • [2] AMELINK A, IN PRESS APPL OPT
  • [3] BARD MPL, UNPUB LUNG CANC
  • [4] In vivo local determination of tissue optical properties:: applications to human brain
    Bevilacqua, F
    Piguet, D
    Marquet, P
    Gross, JD
    Tromberg, BJ
    Depeursinge, C
    [J]. APPLIED OPTICS, 1999, 38 (22) : 4939 - 4950
  • [5] The new World Health Organization classification of lung tumours
    Brambilla, E
    Travis, WD
    Colby, TV
    Corrin, B
    Shimosato, Y
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2001, 18 (06) : 1059 - 1068
  • [6] The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy
    Doornbos, RMP
    Lang, R
    Aalders, MC
    Cross, FW
    Sterenborg, HJCM
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 1999, 44 (04) : 967 - 981
  • [7] A DIFFUSION-THEORY MODEL OF SPATIALLY RESOLVED, STEADY-STATE DIFFUSE REFLECTANCE FOR THE NONINVASIVE DETERMINATION OF TISSUE OPTICAL-PROPERTIES INVIVO
    FARRELL, TJ
    PATTERSON, MS
    WILSON, B
    [J]. MEDICAL PHYSICS, 1992, 19 (04) : 879 - 888
  • [8] Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject
    Fishkin, JB
    Coquoz, O
    Anderson, ER
    Brenner, M
    Tromberg, BJ
    [J]. APPLIED OPTICS, 1997, 36 (01) : 10 - 20
  • [9] Frequency-domain immersion technique for accurate optical property measurements of turbid media
    Gerken, M
    Faris, GW
    [J]. OPTICS LETTERS, 1999, 24 (23) : 1726 - 1728
  • [10] Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers
    Hiroshima, K
    Iyoda, A
    Shibuya, K
    Hoshino, H
    Haga, Y
    Toyozaki, T
    Shiba, M
    Baba, M
    Fujisawa, T
    Ohwada, H
    [J]. CANCER, 2002, 95 (07) : 1539 - 1545