Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats

被引：12

作者：

Marion, Rachel

Baishanbo, Asiya

Gargala, Gilles

Francois, Arnaud

Ducrotte, Philippe

Duclos, Celia

Fioramonti, Jean

Ballet, Jean Jacques

Favennec, Loic

机构：

[1] CHU Charles Nicolle, Parasitol Lab, F-76031 Rouen, France

[2] CHU Charles Nicolle, ADEN, UPRES, EA 3234, F-76031 Rouen, France

[3] CHU Charles Nicolle, Lab Histopathol, F-76031 Rouen, France

[4] Xinjiang Med Univ, Coll Pharm, Urumqi, Peoples R China

[5] INRA, F-31931 Toulouse 9, France

[6] CHU Clemenceau, Lab Immunol & Immunopathol, UPRES, EA 2128, Caen, France

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 07期

关键词：

D O I：

10.1128/IAI.02055-05

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 5-day-old immunocompetent Sprague-Dawley rats infected with either 102 or 105 Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.

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收藏

页码：4387 / 4389

页数：3

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