Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells

被引：59

作者：

Gargala, G

Delaunay, A

Li, XD

Brasseur, P

Favennec, L

Ballet, JJ

机构：

[1] CHU Caen, Lab Immunol & Immunopathol, UPRES EA 2128, F-14033 Caen, France

[2] CHU Rouen, Lab Parasitol Expt, UPRES JE 2008, F-76000 Rouen, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 46卷 / 01期

关键词：

D O I：

10.1093/jac/46.1.57

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effects of nitazoxanide and its metabolites, tizoxanide and tizoxanide glucuronide, on the development of the asexual and sexual stages of Cryptosporidium parvum in differentiated human enterocytic HCT-8 cells were evaluated in a quantitative alkaline phosphatase immunoassay. Nitazoxanide, tizoxanide and tizoxanide glucuronide were inhibitory for up to 46 h when added after sporozoite invasion (MIC50 1.2, 22.6 and 2.2 mg/L, respectively). Tizoxanide had only limited activity, but nitazoxanide and tizoxanide glucuronide strongly inhibited asexual and sexual stages, respectively.

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页码：57 / 60

页数：4

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