Catalytic hydrogenation of α,β-epoxy ketones to form β-hydroxy ketones mediated by an NADH coenzyme model

被引：63

作者：

Xu, Hua-Jian ^{[1
]}

Liu, You-Cheng

Fu, Yao

Wu, Yun-Dong

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Lanzhou Univ, Coll Chem, Lanzhou 730000, Peoples R China

[3] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

[4] Peking Univ, Coll Chem, Beijing, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1021/ol0610892

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydrogenation of alpha,beta-epoxy ketones can be mediated by a catalytic amount of BNAH or BNA(+) Br- to form corresponding,beta-hydroxy ketones in high yield. Na2S2O4 is used as the reducing agent to convert BNA(+) Br- to BNAH. A radical mechanism has been proposed to understand many observations of this catalytic reaction.

引用

页码：3449 / 3451

页数：3

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