Current clinical pathophysiologic considerations in essential hypertension

Over the years, much has been learned from unraveling the pathophysiological alterations associated with the hypertensive diseases. Despite this large base of fundamental and clinical information, our knowledge continues to expand. This article discusses the multifactorial nature of hypertensive disease, including the vascular and cardiac participation in the elevation of arterial pressure and in target organ involvement by the disease. Some of the most exciting advances of the last decade are summarized in this review.