Diclofenac or acetaminophen for analgesia in paediatric tonsillectomy outpatients

被引:75
作者
Romsing, J
Ostergaard, D
Drozdziewicz, D
Schultz, P
Ravn, G
机构
[1] Royal Danish Sch Pharm, Dept Pharmaceut, DK-2100 Copenhagen, Denmark
[2] Gentofte Univ Hosp, Dept Anaesthesiol, Gentofte, Denmark
[3] Gentofte Univ Hosp, Dept Otorhinolaryngol, Gentofte, Denmark
关键词
postoperative analgesia; diclofenac; acetaminophen; children; tonsillectomy;
D O I
10.1034/j.1399-6576.2000.440312.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: In order to establish an effective drug regimen, we compared the analgesic efficacy of oral diclofenac and high-dose acetaminophen on pain after tonsillectomy. Methods: In this randomised, double-blind study 48 children, 5 to 15 years of age, following tonsillectomy were assigned to receive either diclofenac 2-3 mg kg(-1) 24 h(-1) (n=24) or acetaminophen 90 mg kg(-1) 24 h(-1) (n=24) for the first three days after surgery. Postoperative pain was assessed by self-report each day before scheduled medication at 7 h, 12 h, 18 h and 23 h. Results: The number of children rating severe pain was high in both the diclofenac group, 5-50%, and in the acetaminophen group, 12-58%, during the three day study period. Pain scores in the diclofenac group were only significantly lower at 12 h on day 1-3 compared to pain scores in the acetaminophen group (P<0.05). None of the children in the diclofenac group experienced any episodes of nausea/vomiting compared to 9 children in the acetaminophen group on day 1. The incidences of nausea/vomiting increased with pain (P<0.05). None of the 48 children experienced any episodes of bleeding. Conclusions: This study indicates that diclofenac was no more effective than high-dose acetaminophen (90 mg vs. 60 mg kg(-1) 24 h(-1)) for analgesia, but resulted ina lower incidence of nausea and vomiting in patients following tonsillectomy.
引用
收藏
页码:291 / 295
页数:5
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