Dengue vaccine: hypotheses to understand CYD-TDV-induced protection

被引：142

作者：

Guy, Bruno ^{[1
]}

Jackson, Nicholas ^{[1
]}

机构：

[1] Sanofi Pasteur, Res & Dev, F-69007 Lyon, France

来源：

NATURE REVIEWS MICROBIOLOGY | 2016年 / 14卷 / 01期

关键词：

NEUTRALIZING ANTIBODY-LEVELS; CROSS-REACTIVE B; CD8(+) T-CELLS; VIRUS-INFECTIONS; TETRAVALENT VACCINE; DENDRITIC CELLS; TIME-INTERVAL; INAPPARENT; RESPONSES; CHILDREN;

D O I：

10.1038/nrmicro.2015.2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue virus (DENV) is a human pathogen with a large impact on public health. Although no vaccine against DENV is currently licensed, a recombinant vaccine - chimeric yellow fever virus-DENV tetravalent dengue vaccine (CYD-TDV) - has shown efficacy against symptomatic dengue disease in two recent Phase III clinical trials. Safety observations were also recently reported for these trials. In this Opinion article, we review the data from recent vaccine clinical trials and discuss the putative mechanisms behind the observed efficacy of the vaccine against different forms of the disease, focusing on the interactions between the infecting virus, pre-existing host immunity and vaccine-induced immune responses.

引用

页码：45 / 54

页数：10

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