Enterococcal peptide sex pheromones: synthesis and control of biological activity

被引：65

作者：

Chandler, JR ^{[1
]}

Dunny, GM ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

来源：

PEPTIDES | 2004年 / 25卷 / 09期

关键词：

pCF10; pAD1; pPD1; Enterococcus faecalis; pheromone; pheromone-inducible conjugative plasmid; PrgZ; PrgY; iCF10;

D O I：

10.1016/j.peptides.2003.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1377 / 1388

页数：12

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