Characteristics of ligand recognition by a glmS self-cleaving ribozyme

被引：43

作者：

Lim, Jinsoo

Grove, Beth C.

Roth, Adam

Breaker, Ronald R. ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 40期

关键词：

gene expression; molecular recognition; ribozymes RNA; structure-activity relationships;

D O I：

10.1002/anie.200602534

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A tweak here, a tweak there: A series of analogues of glucosamine-6-phosphate (GlcN6P, see picture) was used to examine the molecular-recognition characteristics of a glmS ribozyme that is activated by this ligand. Although several functional groups on the ligand are critical for binding, there are opportunities to create new analogues that fully trigger ribozyme action. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6689 / 6693

页数：5

共 23 条

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