Molecular-recognition characteristics of SAM-binding riboswitches

被引：44

作者：

Lim, J

Winkler, WC

Nakamura, S

Scott, V

Breaker, RR ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[3] Takeda Pharmaceut Co Ltd, Chuo Ku, Osaka 5408645, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 06期

关键词：

aptamers; molecular recognition; riboswitches; RNA; structure-activity relationships;

D O I：

10.1002/anie.200503198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A series of analogues of S-adenosylmethionine (SAM) have been used to examine the molecular-recognition characteristics of an RNA genetic element or riboswitch. Biochemical assays indicate that the riboswitch of the SAM-I class is highly selective for SAM and exhibits a pattern of molecular recognition that is distinct from that of the SAM-II class of riboswitches. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：964 / 968

页数：5

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