Novel tools to unravel molecular mechanisms in cilia-related disorders

被引：15

作者：

Fliegauf, Manfred ^{[1
]}

Omran, Heymut ^{[1
]}

机构：

[1] Univ Hosp Freiburg, Dept Pediat & Adolescent Med, D-79106 Freiburg, Germany

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 05期

关键词：

D O I：

10.1016/j.tig.2006.03.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cilia are hair-like organelles extending from the cell surface that execute motile (e.g. respiratory cilia) and/or sensory functions (e.g. renal monocilia). The basic ultrastructure of cilia and flagella has been well established by electron microscopy. Several recent reports have now provided intriguing new insights into the complex molecular composition of cilia and flagella. These data from genome, proteome and transcriptome analyses will facilitate the systematic discovery and understanding of genes responsible for human cilia-related diseases, such as primary ciliary dyskinesia, polycystic kidney disease and male sterility.

引用

页码：241 / 245

页数：5

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