Influence of pharmacological agents on portal hemodynamics:: Basis for its use in the treatment of portal hypertension

被引:59
作者
García-Pagán, JC [1 ]
Escorsell, A [1 ]
Moitinho, E [1 ]
Bosch, J [1 ]
机构
[1] Univ Barcelona, IDIBAPS, IMD, Liver Unit,Hepat Hemodynam Lab, E-08007 Barcelona, Spain
关键词
portal hypertension; liver cirrhosis; hemodynamics; portal pressure; esophageal and gastric varices;
D O I
10.1055/s-2007-1007130
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Progress in the knowledge of the pathophysiology of portal hypertension has opened the door to pharmacological treatments, resulting in a dramatic change in the therapeutic approach to portal hypertension. This review summarizes pharmacological agents that have bern shown to effectively decrease portal pressure, paying special attention to its mechanisms of action. In addition, the way to monitor response and clinical efficacy of pharmacological agents is reviewed.
引用
收藏
页码:427 / 438
页数:12
相关论文
共 112 条
[41]  
Feu F., 1995, Journal of Hepatology, V23, P69
[42]  
GARCIAPAGAN JC, 1994, HEPATOLOGY, V19, P1095, DOI 10.1002/hep.1840190506
[43]   LYMPHOCYTE-BETA-2-ADRENOCEPTORS AND PLASMA-CATECHOLAMINES IN PATIENTS WITH CIRRHOSIS [J].
GARCIAPAGAN, JC ;
NAVASA, M ;
RIVERA, F ;
BOSCH, J ;
RODES, J .
GASTROENTEROLOGY, 1992, 102 (06) :2015-2023
[44]   LONG-TERM HEMODYNAMIC-EFFECTS OF ISOSORBIDE 5-MONONITRATE IN PATIENTS WITH CIRRHOSIS AND PORTAL-HYPERTENSION [J].
GARCIAPAGAN, JC ;
FEU, F ;
NAVASA, M ;
BRU, C ;
DELARBOL, LR ;
BOSCH, J ;
RODES, J .
JOURNAL OF HEPATOLOGY, 1990, 11 (02) :189-195
[45]   ENHANCEMENT OF PORTAL PRESSURE REDUCTION BY THE ASSOCIATION OF ISOSORBIDE-5-MONONITRATE TO PROPRANOLOL ADMINISTRATION IN PATIENTS WITH CIRRHOSIS [J].
GARCIAPAGAN, JC ;
NAVASA, M ;
BOSCH, J ;
BRU, C ;
PIZCUETA, P ;
RODES, J .
HEPATOLOGY, 1990, 11 (02) :230-238
[46]   PROPRANOLOL COMPARED WITH PROPRANOLOL PLUS ISOSORBIDE-5-MONONITRATE FOR PORTAL-HYPERTENSION IN CIRRHOSIS - A RANDOMIZED CONTROLLED-STUDY [J].
GARCIAPAGAN, JC ;
FEU, F ;
BOSCH, J ;
RODES, J .
ANNALS OF INTERNAL MEDICINE, 1991, 114 (10) :869-873
[47]   NICARDIPINE INCREASES HEPATIC BLOOD-FLOW AND THE HEPATIC-CLEARANCE OF INDOCYANINE GREEN IN PATIENTS WITH CIRRHOSIS [J].
GARCIAPAGAN, JC ;
FEU, F ;
LUCA, A ;
FERNANDEZ, M ;
PIZCUETA, P ;
BOSCH, J ;
RODES, J .
JOURNAL OF HEPATOLOGY, 1994, 20 (06) :792-796
[48]   Propranolol plus molsidomine vs propranolol alone in the treatment of portal hypertension in patients with cirrhosis [J].
GarciaPagan, JC ;
Escorsell, A ;
Feu, F ;
Bandi, JC ;
Moitinho, E ;
Casado, M ;
Bosch, J ;
Rodes, J .
JOURNAL OF HEPATOLOGY, 1996, 24 (04) :430-435
[49]  
GARCIAPAGAN JC, 1989, ARES SERONA S REV, V22, P287
[50]   SHORT-TERM EFFECTS OF PROPRANOLOL ON PORTAL VENOUS-PRESSURE [J].
GARCIATSAO, G ;
GRACE, ND ;
GROSZMANN, RJ ;
CONN, HO ;
BERMANN, MM ;
PATRICK, MJC ;
MORSE, SS ;
ALBERTS, JL .
HEPATOLOGY, 1986, 6 (01) :101-106