More than just a filler - the role of hyaluronan for skin homeostasis

被引：76

作者：

Anderegg, Ulf ^{[1
]}

Simon, Jan C. ^{[1
]}

Averbeck, Marco ^{[1
]}

机构：

[1] Univ Leipzig, Dept Dermatol Venerol & Allergol, D-04109 Leipzig, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 05期

关键词：

fillers; hyaluronan; metabolism; skin; skin regeneration; ALPHA-TRYPSIN INHIBITOR; SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; FETAL WOUND FLUID; IN-VITRO; EXTRACELLULAR-MATRIX; SYNTHASE; INTRACELLULAR HYALURONAN; PERICELLULAR MATRIX; SYSTEMIC-SCLEROSIS;

D O I：

10.1111/exd.12370

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

In recent years, hyaluronan (HA) has become an increasingly attractive substance as a non-immunogenic filler and scaffolding material in cosmetic dermatology. Despite its wide use for skin augmentation and rejuvenation, relatively little is known about the molecular structures and interacting proteins of HA in normal and diseased skin. However, a comprehensive understanding of cutaneous HA homeostasis is required for future the development of HA-based applications for skin regeneration. This review provides an update on HA-based structures, expression, metabolism and its regulation, function and pharmacological targeting of HA in skin.

引用

页码：295 / 303

页数：9

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