DISACCHARIDE ANALYSIS OF THE SKIN GLYCOSAMINOGLYCANS IN SYSTEMIC-SCLEROSIS

被引：37

作者：

AKIMOTO, S ^{[1
]}

HAYASHI, H ^{[1
]}

ISHIKAWA, H ^{[1
]}

机构：

[1] GUNMA UNIV,INST ENDOCRINOL,DEPT PROT CHEM,MAEBASHI,GUNMA 371,JAPAN

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1992年 / 126卷 / 01期

关键词：

D O I：

10.1111/j.1365-2133.1992.tb08399.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The disaccharides constituting chondroitinase-digestible glycosaminoglycan (GAG) in the skin lesions of patients with systemic sclerosis were determined using high-performance liquid chromatography (HPLC). In scleroderma there was an increase in the amount of DELTA-Di-4S(DS), the main disaccharide unit of dermatan sulphate, and a decrease in DELTA-Di-HA, the disaccharide unit of hyaluronic acid, as compared with normal skin from a similar site. The distribution pattern of the main disaccharides constituting chondroitin sulphate and dermatan sulphate in scleroderma differed from that in scars or scleredema.

引用

页码：29 / 34

页数：6

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