Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci

被引:54
作者
Hoellman, DB
Pankuch, GA
Jacobs, MR
Appelbaum, PC [1 ]
机构
[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
关键词
D O I
10.1128/AAC.44.4.1085-1088.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
GAR-936, a nem glycylcycline, had lo,ver MICs (less than or equal to 0.016 to 0.125 mu g/ml) for 201 peniciliin- and tetracycline-susceptible and -resistant pneumococcal strains than tetracycline (less than or equal to 0.06 to 128 mu g/ml), minocycline (less than or equal to 0.06 to 16.0 mu g/ml), or doxycycline (less than or equal to 0.06 to 32.0 mu g/ml). GAR-936 was also bactericidal against 11 of 12 strains tested at the MIC after 24 h, with significant kill rates at earlier time points.
引用
收藏
页码:1085 / 1088
页数:4
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