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MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms

被引：55
作者：
Holliday, Gemma L.
Almonacid, Daniel E.
Bartlett, Gail J.
O'Boyle, Noel M.
Torrance, James W.
Murray-Rust, Peter
Mitchell, John B. O.
Thornton, Janet M.
机构：
[1] EMBL EBI, Cambridge CB10 1SD, England
[2] Univ Cambridge, Dept Chem, Unilever Ctr Mol Sci Informat, Cambridge CB2 1EW, England
来源：
NUCLEIC ACIDS RESEARCH | 2007年 / 35卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1093/nar/gkl774
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MACiE (Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and is publicly available as a web-based data resource. This paper presents the first release of a web-based search tool to explore enzyme reaction mechanisms in MACiE. We also present Version 2 of MACiE, which doubles the dataset available (from Version 1). MACiE can be accessed from http://www.ebi.ac.uk/thornton-srv/databases/MACIE/.
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收藏
页码：D515 / D520
页数：6
相关论文
共 17 条
[11]   PDBsum more: new summaries and analyses of the known 3D structures of proteins and nucleic acids [J].
Laskowski, RA ;
Chistyakov, VV ;
Thornton, JM .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D266-D268
[12]   PDBSprotEC: A web-accessible database linking PDB chains to EC numbers via SwissProt [J].
Martin, ACR .
BIOINFORMATICS, 2004, 20 (06) :986-988
[13]   EzCatDB: the Enzyme Catalytic-mechanism Database [J].
Nagano, N .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D407-D412
[14]   CATH - a hierarchic classification of protein domain structures [J].
Orengo, CA ;
Michie, AD ;
Jones, S ;
Jones, DT ;
Swindells, MB ;
Thornton, JM .
STRUCTURE, 1997, 5 (08) :1093-1108
[15]   Leveraging enzyme structure-function relationships for functional inference and experimental design: The structure-function linkage database [J].
Pegg, SCH ;
Brown, SD ;
Ojha, S ;
Seffernick, J ;
Meng, EC ;
Morris, JH ;
Chang, PJ ;
Huang, CC ;
Ferrin, TE ;
Babbitt, PC .
BIOCHEMISTRY, 2006, 45 (08) :2545-2555
[16]   The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data [J].
Porter, CT ;
Bartlett, GJ ;
Thornton, JM .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D129-D133
[17]   BRENDA, the enzyme database: updates and major new developments [J].
Schomburg, I ;
Chang, A ;
Ebeling, C ;
Gremse, M ;
Heldt, C ;
Huhn, G ;
Schomburg, D .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D431-D433
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